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Advances in the Inhibitory Mechanism of Mesenchymal Stem Cells on Tumor Cells Proliferation
Zhang Jingsi, Hou Lingling*, Hu Honggang, Yan Qiong
College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing 100044, China
Abstract: Mesenchymal stem cells (MSCs) which can be obtained from a variety of tissues possess a multipledifferentiation potential towards osteoblasts， adipocyte， chondrocytes and other cells. Previous studies have reported that MSCs can inhibit tumor cells proliferation by two means. At first， MSCs-derived exosomes and cytokines directly reprogram the signaling pathway and regulate the expression of growth factors. Secondly， engineered MSCs can deliver multiple agents and suicide genes straightly into the tumor tissues. Here， we reviewed the direct and indirect inhibitory mechanism of MSCs on growth and progression of tumor cells.
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