Home > Browse Issues > Vol.36 No.12
Progress of miRNAs Research in Hepatocellular Carcinoma Gene Therapy
Liu Hao1, Huang Xiaoming1, Wang Jia1,2, Jia Zhenyu1*
1Zhejiang Academy of Medical Sciences, Hangzhou 310013, China;
2School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325025, China
Abstract: Hepatocellular carcinoma (HCC) is by far the most common type of liver cancers， accounting for 70%~85% of cases， with high mortality worldwide. Curative effect of therapeutic treatments for HCC is rather limited. Alteration and relative mechanism of biological macromolecules in HCC development and progress are the basis of novel therapy exploration. microRNAs are small non-coding RNAs， which play important roles in biological processes， such as gene expression and protein translation. Dysregulation of microRNAs is involved in tumor occurrence and progress. Gene therapy has emerged as a new treatment option for various diseases， including cancer. Therefore， microRNAs are investigated as potential targets and promising strategies of HCC gene therapy. In this article， microRNAs were reviewed on their functional mechanism， involvement in HCC and advancement in HCC gene therapy.
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