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The Research Advance in Application of Dental Stem Cells for Repairing Injured Tissues
Deng Qinnan1,2, Zhang Bin2,3, Gao Junyu3, Han Fabin2,3*
1Dr. Samuel QN. Deng Dental Clinic, San Francisco, CA94123, USA;
2Shandong Provincial Key Laboratory for Oral & Facial Medical Biology, Liaocheng People’s Hospital/the Affiliated Liaocheng Hospital, Taishan Medical University,Liaocheng 252000, China;
3Center for Stem Cells and Regenerative Medicine, Liaocheng People’s Hospital/the Affiliated Liaocheng Hospital, Taishan Medical University, Liaocheng 252000, China
Abstract: Dental stem cells (DSCs) are mesenchyme stem cells isolated from human teeth and the associated tissues around the teeth. Since the isolation of dental pulp stem cells (DPSCs) from dental pulp of teeth in the year of 2000, seven kinds of dental stem cells have been isolated and characterized. In recent years, researches on the characterization and biological functions of DSC have been widely investigated in the basic and clinical application of DSC. This review summarized the recent progress in using DSC to repair the teeth and teethassociated tissues. In addition, the research applications of DSC in stroke, spinal cord injury, Parkinson’s disease, cardiac infarction, diabetes and immune-deficient disorders are discussed in this review.