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The Clinical Significance of Gankyrin Expression in Papillary Thyroid Carcinoma
Xu Jinye1, Shen Qinyan1, Xing Ping1, Lai Yongfeng1, Jin Xiaoyan2, Liang Yong2,3*
1The First Affiliated Hospital,Wenzhou Medical University, Wenzhou 325000, China;
2Department of Oncologic Surgery, the Affiliated Municipal Hospital, Taizhou University, Taizhou 318000, China; 3Medical School, Taizhou University,Taizhou 318000, China
Abstract: In this research， we evaluated the relationship between gankyrin expression and clinicopathologic parameters in papillary thyroid carcinoma (PTC)， exploring its effect on PTC using fluorescence quantitative PCR， Western blot and immunohistochemistry to investigate mRNA and protein levels of gankyrin in PTC， Hashimoto’s thyroiditis (HT) and normal thyroid tissues. The results showed that both the mRNA and protein levels of gankyrin expression in PTC and HT were obviously higher than that in normal thyroid tissues (P<0.01)， whereas the differences of gankyrin expression were not significant between PTC and HT (P>0.05). In addition， gankyrin was overexpressed in PTC with coexisting of HT compared with PTC without HT. The high level of gankyrin expression in both PTC and HT suggests that gankyrin plays an important role in the occurrence and development of these two closely related diseases and it is probably a molecular mechanism of PTC.
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