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Molecules Mechanism of Sperm-oocyte Fusion
Xiao-Qiang Guo*, Cai-Qing Yang1
Department of Biochemistry, Bethune Military Medical College, Shijiazhuang 050081, China; 1Department of Dingzhou, Baoding Normal College, Dingzhou 073000, China
Abstract: Sperm-oocyte fusion is one of the most key events in sexual reproduction， so it has an important significance to understand its molecular mechanism. There are several molecules that involved in sperm-oocyte fusion， such as CD9， glycosylphosphatidylinositol-anchored proteins and integrins on oocytes， and epididymal protein DE， Izumo and ADAMs on sperm. These molecules assist to complete sperm-egg fusion by special recognition and binding. These progress has vital application in developing new methods for both fertility regulation and diagnosis and treatment of human infertility.
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