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Quorum Sensing System in the Regulation of Staphylococcal Virulence
Hong-Wei Zhu1, Zhan-Bo Zhu1, Yu-Dong Cui2*
1College of Animal Science and Technology, 2College of Life Science and Technology, Heilongjiang August First Land Reclamation University, Daqing 163319, China
Abstract: Cell-density-dependent multi-gene regulation system (quorum sensing) in bacteria enables staphylococcal cells to sense the environmental information and regulate the expression of numerous virulence factors via the autoinduction and signal transduction pathway. Expression of these virulence factors is tightly controlled by numerous regulatory loci such as agr， sae， and arl etc， as well as by proteins with homology to Sar family. In addition， quorum sensing is required for the formation and development of biofilm which is close related to the staphylococcal virulence and drug resistance. Targeting to disrupt the autoinduction of quorum sensing systems might in principle constitute a reasonable way to find novel antibacterial drugs.
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