Progress in Immunologic Mechanism of Helicobacter pylori Infection and Gastric Mucosa Lesion

Abstract: Helicobacter pylori (H.pylori) is one of the most common pattern pathogenic bacteria and pathogens in human. Their contact with the gastric epithelium and colonization may cause the host innate and adaptive immune abnormalities through a series of complex biological processes， and thus lead to gastric mucosal damage， ulcer or even precancerous lesions， also involve a number of extra-gastrointestinal diseases. Inflammatory reaction is an important pathophysiological mechanism in mucosal lesion of H. pylori infection. During this process， by virtue of the complex and delicate mucosal immune regulation function， probably， gastric epithelial cell is not only the first line of defense against H. pylori infection， but also an initiative or direct participant. It plays an important role in the local defense or pathophysiological process of immune injury， which is closely related to the molecular control in innate immunity as pattern recognition receptors. With the infection and injury mechanism of H. pylori， how to continue the study both on the cellular and molecular level and bacteria versus host， how to strengthen the immune intervention， individualized treatment and social prevention， may be the key issues in the basic and clinical study.
    

CSTR: 32200.14.cjcb.2009.03.0009