Home > Browse Issues > Vol.29 No.3
The Effect of Dendritic Cells Migration and Anti-adhesive Regulation on Renal Tubulointerstitial Inflammation
Min-Chao Cai, Jie Zou, Tong Zhou*
Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: Inflammatory cells infiltration into renal interstitium and immune reaction stimulated by injury factors play key role in early stage of renal tubulointerstitial lesion and fibrosis. It has been proved that dendritic cells (DCs) migration into the renal tissue under the circumstances of inflammation and the inflammatory immune reaction triggered by DCs migration are closely relevant to the injury of renal tubulointerstitium. It is not only the pathologic basis of the fibrosis， but also the critical factor of renal immune pathologic mechanism. The adhesion molecules such as selectins contribute to DCs migration into the renal tissue and inflammatory immune reaction. And anti-adhesive regulation has achieved satisfactory results， which may be a new approach to preventing and treating the renal tubulointerstitial lesion and fibrosis.
CN
EN