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Ezrin: Biological Characteristics and Roles in Cancer Metastasis
Hang-Qing Lu, Jie Zheng1*
Experiment Center of Modern Medicine; 1Institute of Molecular Pathology, Department of Pathology and Pathophysiology, School of Basic Medicine, Southeast University, Nanjing 210009, China
Abstract: Ezrin is a member of the ezrin-radirin-moesin (ERM) family， which primarily acts as links between the plasma membrane and the cytoskeleton. Ezrin has been implicated in many roles， such as involved in epithelial cell morphogenesis， formation of microvilli， cell adhesion sited and signal transduction. Recent study revealed that ezrin was abnormal expression in many cancers， suggesting that the ezrin is also involved to the invasion and metastasis of cancers.
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