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LMO2 and T Cell Leukemia
Na Wang1,2, Yong Zhao1,2,3*
1Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China; 2Graduate School of the Chinese Academy of Sciences
Abstract: Lmo2， as an oncogene， is one of the members of the LMO (LIM-only) family. Its aberrant transcription and expression in T cells caused by translocation t(11; 14) (p13; q11) or t(7; 11) (q35; p13) was found to be associated closely with T cell acute lymphoblastic leukemia. LMO2 is an important molecule mediating the formation of transcription factor complex in normal hematopoietic cells. We herein reviewed the molecular structure and the likely mechanisms of LMO2 in the occurrence of leukemia caused by blocking T cell differentiation. Furthermore， the possibility for the development of LMO2-associated leukemia in patients with X-linked severe combined immunodeficiency after retroviral-mediated gene therapy was also discussed.
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