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Progress in JNK Signaling
Yu-Qi Yao, Xiao-Mei Li*
Department of Nephrology, Peking University the First Hospital; Institute of Nephrology, Peking University, Beijing 100034, China
Abstract: c-Jun N-terminal kinase (JNK) family is one of members of mitogen-activated protein kinase (MAPK) superfamily. The JNK signal pathway can be activated by cytokines， growth factors， stresses， and so on. Many studies suggested that the JNK signal pathway plays a pivotal role in cell differentiation， apoptosis， stress， the initiation and progress of considerable human diseases. In this review， we mainly focus on the constitute， regulation， "cross talk"about JNK signal pathway.
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