Home > Browse Issues > Vol.27 No.3
MPM-2 Phosphoprotein Family and Their Regulators
Hong Li1,2, Jin Liu1, Xiang MA1, Fang Lao1, Chang-Qing Zeng1,3, Da-Cheng He1*
1Institute of Cell Biology, Beijing Normal University, Beijing 100875, China; 2College of Biology and Engineering, Hebei University of Science and Technology Shijiazhuang 050018, China; 3Beijing Genomics Institute, Chinese
Abstract: Monoclonal antibody MPM-2， which recognizes a large family of mitotic phosphoproteins in a phosphorylation- dependent manner， fully allures our attention. It is suggested that MPM-2 phosphoproteins play an important role in regulating mitotic processes for some of the MPM-2 phosphoproteins being present in components of the mitotic apparatus such as centrosomes， kinetochores， spindle fibers， chromosomes scaffolds and the midbody. In this review， we will integrate our research work with others and summarize the studies on the distribution of MPM-2 phosphoproteins and briefly describe related findings for the functional importance of MPM-2 phosphoprotein in the mitotic progress. We will provide the results of partial characterization of MPM-2 phosphoepitope and the identification and characterization of the MPM-2 phosphoproteins， the studies results on regulators of MPM-2 phosphoproteins as well.
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