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Establishment of Serum Proteomic Patterns for Screening Endometriosis by SELDI-TOF-MS
Liang Wan1, Wei Zheng1, Jie-Kai Yu2, Wen-Zhi Jiang2, Lin Mu1, Su-Zhan Zhang3*
1Department of Gynecology, 2Cancer Institute, 3Department of Oncology, the Second Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310006, China
Abstract: To detect the serum proteomic patterns in endometriosis patients by using SELDI-TOF-MS protein chip array， build diagnostic models and evaluate its clinical significance. SELDI-TOF-MS protein chip was used to detect the serum proteomic patterns of 16 patients with endometriosis and 16 normal women， and the diagnostic models were developed. Then， the blinding test was performed on those endometriosis patients and healthy individuals. Four potential biomarkers were found (8 141， 6 096， 5 894， 3 269 m/z)， and the diagnostic system separated the endometriosis from the healthy samples with a sensitivity of 87.5% (14/16) and a specificity of 93.75% (15/16). The method showed high sensitivity and specificity and great potential for the detection and screening better biomarkers for endometriosis.
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