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Gene Expression Profiles Analysis Related to Invasion of Trophoblasts
Cai-Bo Fan1,2, Jun-Lin He1*, Ying-Xiong Wang1, Xue-Qing Liu1, Xue-Mei Chen1, Yu-Bin Ding1
1Laboratory of Reproductive Biology, Department of Genetics, School of Public Health; 2Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, China
Abstract: Cytotrophoblast cells (CTB) and extravillous trophoblast cells (EVT) from 8 week to 12 week normal villous and deciduas were separated and collected. The total RNA of CTB and EVT were extracted respectively. The CTB and EVT gene chip hybridization and gene expression profiles data extraction were performed in Shanghai Biochip Limited Company. The differential expression gene between CTB and EVT were analyzed by computer. We found 1 318 differential expression genes (813 genes up-regulated and 505 genes down-regulated respectively) and queried their biological functions and classified categories according to the standard of Gene Ontoloty. This study would help us to reveal the mechanism of gene network regulation in EVT invasion in early embryo development.
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