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Anti-tumor Activity and Mechanism of Oridonin
Xiang Li, Li-Hong Ye1, Ji-Chen Li*
Institute of Cell Biology, Zhejiang University, Hangzhou 310058, China, 1Urology Department, Shaoxing Fouth Hospital, Shaoxing 312030, China
Abstract: Oridonin (ORI) is an active natural diterpenoid product isolated from Rabdosia rubescens. It has various pharmacological activities， including anti-inflammation， antibacteria and antitumor. Recent studies have focused on the growth inhibition and apoptosis induced by ORI. The mechanisms of the latter action may involve activation of death receptor-mediated pathways， mitochondria-mediated pathways， MAPK pathways or blockade of PI3K/Akt pathway. Further， the autophagy induced by ORI is reported to facilitate tumor cells to delay or escape partially from apoptosis.
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