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Role of P-selectin in Cell Adhesion and Thrombosis
Ya-Peng Zhao, Pei-Pei Jin1, Tong Zhou*, Xue-Feng Wang1
Department of Nephrology, 1Department of Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,
Abstract: P-selectin is critical cell molecule of selectin family， which plays a significant role in inflammatory response， blood coagulation and thrombosis by regulating the initial interactions between leukocytes and the blood vessel wall as well as between activated platelets and leukocytes. Multiple studies have shown that these adhesion molecules are not only required for the normal recruitment of leukocytes during an inflammatory reaction but also are important in recruitment of leukocytes and leukocyte microparticles to thrombi and for normal tissue factor accumulation and fibrin generation in thrombi. The inhibition of interaction of P-selectin with the ligand could down regulate cytokine and tissue factor expression and repress recruitment of leukocytes. All of these lead to new targets for antithrombotic therapy.
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