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Hyperplasia Suppressor Gene HSG/Mfn2
Li-Hua Dong, Mei Han*, Jin-Kun Wen
Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China
Abstract: Hyperplasia suppressor gene (HSG， re-named mitofusin-2， Mfn2) is a novel gene identified by Kuang-Hueih Chen using a differential display technique. HSG/Mfn2 antiproliferative effect is mediated by inhibition of ERK/MAPK signalling and subsequent G0/G1 cell-cycle arrest. HSG/Mfn2 is associated with smooth muscle (SM) α-actin in vascular smooth muscle cell (VSMC)， its expression is related with VSMC differentiation and plays important roles in regulation of VSMC phenotype. In addition， HSG/Mfn2 mediates mitochondrial fusion and is associated with mitochondrial size， morphology and function. HSG/Mfn2 is an important therapeutic target for treatment of vascular proliferative disorders and other hyper-proliferative diseases as well.
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