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Progress in Microtubule Plus-end Tracking Proteins
Kai Jiang, Xue-Biao Yao*
Anhui Key Lab of Cellular Dynamics & Chemical Biology, University of Science and Technology of China, Hefei 230027, China
Abstract: Microtubule plus-end tracking proteins (+TIPs) are a group of conserved proteins that all concentrate at the polymerizing microtubule plus-end in spite of their differences in molecular architecture and cellular function. Plastic networks are formed through the modest interactions between their functional domains， which make them easily adapt to the dynamic environment. By regulating microtubule dynamics， microtubule attachments with cellular organelles and signaling factors， and exerting forces on microtubule networks， +TIPs play various roles in organizing cell architecture and cellular activities.
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