Home > Browse Issues > Vol.29 No.1
Transdifferentiation of Bone Marrow Mesenchymal Stem Cells into Islet Cells to Treat Diabetes Mellitus
Yi-Hua Zhang, Zhong-Ying Dou*
The Research Centre of Stem Cell Engineering Technique in Shaanxi Province, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, China
Abstract: Diabetes mellitus is a serious disease damaging human being's health. At present， the curative effect of transplantation of pancreatic islets used to treat diabetes mellitus appears. However， it is limited with the lack of pancreatic islets and immunological rejection. Bone marrow mesenchymal stem cells (BMMSCs)， easily separated， cultured and purified， have multi-differentiation potential. If BMMSCs are induced to transdifferentiate into islet cells， the problems of lacking pancreatic islets and immunological rejection can be entirely solved， and diabetes mellitus can be cured with patient's marrow cells. In this paper， the progress of transdifferentiation from BMMSCs into islet cells to treat diabetes mellitus was fully reviewed， and the problems and research directions were discussed.
CN
EN