Home > Browse Issues > Vol.36 No.10
Research Progress on the Role of Puma in Cancer and Stem Cells
Zhao Lei, Yuan Weiping, Cheng Tao*
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
Abstract: Puma (p53 upregulated modulator of apoptosis)， a Bcl-2 homology 3 (BH3)-only Bcl-2 family member， mediates cell apoptosis through a p53-dependent or p53-independent pathway and participates in the regulation of biological processes to maintain cellular homeostasis. In recent years， more attentions have been ven to the roles of Puma in the development of human malignancies and in the protection of stem cells upon injury. A better understanding of the mechanism of Puma-induced apoptosis in cancer and stem cells would be helpful in the pursuit of new therapeutic treatments for relevant diseases. In this review， the molecular features of Puma， biochemical functions of Puma in apoptosis and especially its roles in cancer and stem cells were discussed.
CN
EN