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Regulation and Outcome of Pancreatic Stellate Cells
Wu Chunhua, Sun Zilin, Yang Jiayue, Chen Bijun, Li Fengfei, Li Ling*
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Southeast University, Nanjing 210009, China
Abstract: Pancreatic fibrosis， a characteristic histopathological feature of chronic pancreatitis， is no longer considered as a static or unidirectional event， but a dynamic and regulated process that may be reversible in the early stages. Activated pancreatic stellate cells (PSCs) play a central role in fibrogenesis associated with pancreatitis. Direct inhibition of PSCs proliferation， migration and ECM production or even reversion of the PSCs activation process， as well as induction of apoptosis in activated PSCs to eliminate these cells， might be promising strategies to treat fibrosis. This review describes therapeutic targeting of PSCs representing a promising new strategy for reducing fibrogenesis.
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