The Dual Function of ERα Coregulators in the Breast Cancer

Abstract: The health of women is facing the threat of malignant breast carcinoma， especially in many developed countries. Estrogen receptor alpha (ERα) is a kind of ligand dependent transcription factor， which mediates downstream targeted genes transcriptional regulation， playing an important role in the process including proliferation， differentiation and invasion of breast carcinoma cells. ERα regulates the expression of downstream target genes mainly depending on its coregulators. Recently， studies have confirmed that many coactivators or corepressors of ERα can significantly regulate it’s transcriptional activation. Meanwhile， they act as ubiquitin E3 ligase to promote the degradation of ERα. Here， we review the dual function of ERα coregulators in breast cancer. This study may explain the molecular mechanism about ERα expression difference involved in different types of breast cancer cells and provide a new perspective on prevention and targeted therapy.

CSTR: 32200.14.cjcb.2014.10.0017