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The Niche Regulate Fate of Spermatogonial Stem Cells
Wang Feng, Wang Shanlin, Chen Zheng, An Na, Yuan Lifang, Li Zongyue, Zhu Baochang*
College of Life Science, Capital Normal University, Beijing 100048, China
Abstract: The spermatogenesis is sophisticately regulated by many growth factors. Self-renewal of spermatogonial stem cells maintain their own population， while， differentiations of SSCs ultimately provide enough mature sperms. SSC activities are regulated by their niche microenvironment. Stem cell niches are formed by contributions of surrounding cells that provide a milieu of growth factors and specialized microarchitecture to promote self-renewal and differenciation of stem cells. In this review， our attempts have been made to focus on new knowledge about niche microenvironment and factors that control self-renewal and differentiation of spermatogenesis. In addition， perspective study for medical care and research fields are discussed briefly.
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