Home > Browse Issues > Vol.36 No.10
DNA Methylation in Coronary Heart Disease
Ye Huadan, Hong Qingxiao, Tang Linlin, Zhou Annan, Jiang Danjie, Li Yirun, Dai Dongjun, Duan Shiwei*
Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Coronary heart disease (CHD) is a type of cardiovascular disease that has become a major cause of human deaths in the western countries. CHD is a complex disease driven by the interaction of many factors from both environment and genetics. The environmental factors contributing to CHD include hypoxia， alteration of prenatal environment， smoking， environmental pollution and unhealthy lifestyle diet. The in vivo and in vitro changes of environmental factors can lead to the alteration of epigenetic modification such as DNA methylation. Aberrant DNA methylation levels can influence the expression of genes and contribute to the risk of CHD. Current researches of DNA methylation mainly focus on genes related with estrogen receptor， immune， lipid metabolism， oxidative stress， blood coagulation and 9p21 genes. Our review summarized the contribution of DNA methylation to the risk of CHD based on the latest progress of DNA methylation research.
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