Progress in Researches of SUN-domain Protein Family

Abstract: SUN (Sad-1， UNC-84) proteins widely exist in eukaryotic organisms including Saccharomyces lysate and C. elegant， localizing in nuclear envelop and endoplasmic reticulum (ER) as a family of membrane binding proteins. The phenotypes of mutant UNC-84 in Saccharomyces lysate are consistent with those of mutant Sad-1， and these species share high sequence homology in the C-terminal of the domain (about 50 percent). So we call it SUN domain， and the family members all consist of SUN domain. According to different localization of SUN domain in protein primary structure， we divide them into classic and non-classic proteins. Classic proteins often function in interacting with KASH (Klarsicht， ANC-1， and Syne homology) proteins. Many studies indicated that SUN-domain proteins might participate in nuclear positioning， nuclear envelope remolding， cell migration and protein synthesis. The complex formed with SUN proteins has a significant relationship with the formation and development of progressive muscular dystrophy. This review focuses on the recent progress in the structure and functions of SUN-domain family of proteins.

CSTR: 32200.14.cjcb.2014.10.0014