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Role of Retinoic Acid in the Regulation of Spermatogenesis
Chen Yao, Tong Minghan*
Shanghai Key Laboratory of Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Retinoic acid， an active metabolite of vitamin A， has been shown to be essential for mammalian spermatogenesis. However， the molecular mechanisms underlying this requirement remain to be determined. The goal of this review is to outline retinoic acid transport， metabolism and signaling in testis. Finally， this review will explore the role of retinoic acid in the regulation of spermatogenesis.
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