The Progress of Genetic-modified Pigs as Donors in Xenotransplantation

Abstract: Organ transplantation is an ultimate method for treating terminal organic disorder. Lacking of organs is the most serious impediment to the development of organ transplantation. Xenotransplantation opens the door to solve this problem. Pigs are the most ideal donors whose anatomy and physiology are remarkably similar to human. Genetic-modified pigs play key roles in xenotransplantation. This paper reviewed the researches about the mechanisms of pig-human xenotransplantation immune rejection and how to overcome immune rejection， the physiological functions of organ after transplantation， as well as the possible risk of virus infection which provide a theoretical basis for xenotransplantation.

CSTR: 32200.14.cjcb.2014.09.0013