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Spindle Assembly Checkpoint: Guardian of Chromosome Stability
Wang Zhikai, Zhu Lijuan, Dou Zhen, Yao Xuebiao*
Anhui Key Laboratory of Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei 230027, China
Abstract: The eukaryotic life stems from cell division by which parental genome is segregated into two daughter cells. To achieve the equal distribution， protein machinery named spindle assembly checkpoint (SAC) ensures all chromosomes bi-oriented and accurately attached to spindle microtubule prior to anaphase initiation. Perturbation of SAC assembly dynamics and functional plasticity contribute to chromosome instability and aneuploidy that contribute to tumorigenesis. This essay highlights recent progresses towards a better understanding of SAC. We also discuss the perspectives of future research on this exciting avenue.
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