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bFGF Regulates the Expression of Myostatin Partially through MAPK Signal Pathway
Zhai Lili1, Wang Wei2, Yu Fang2, Zhang Yong1*, Zhu Dahai1*
1Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; 2Harbin Institute of Technology, Harbin 150001, China
Abstract: Myostatin (MSTN)， a member of transforming growth factor-β (TGF-β) superfamily， is a negative regulator of the skeletal muscle growth by suppressing the proliferation and differentiation of myoblast. In this study， MSTN is up-regulated by basic fibroblast growth factor (bFGF) in a dose and time-point dependent manner. Moreover， MAPK signal pathway is found to partially participate in the effect on Myostatin gene expression induced by bFGF.
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