Home > Browse Issues > Vol.36 No.8
Direct Reprogramming of Fibroblasts into Cardiomyocyte
Wang Yanyan1, Shi Shujun1, Liu Huiwen1*, Meng Li2
1School of Basic Medical Sciences, Harbin Medical University, Harbin 150081; 2California Fertility Partners Inc. Los Angeles CA 90025, USA
Abstract: Recently functional cardiomyocytes can be generated directly from fibroblasts using several combinations of cardiac transcription factors or microRNAs in mouse and human. The cells have similar global cardiac gene-expression patterns with cardiomyocytes， and some of them have sarcomere formation and spontaneous contraction. Direct cardiomyocyte reprogramming potentially offers an attractive strategy to cardiovascular regenerative medicine by converting cardiac fibroblasts into functional cardiomyocytes in situ. This paper reviews the new research progress of direct reprogramming of mouse and human fibroblasts into cardiomyocytes in vitro and in vivo， and discusses value and method of direct cardiac reprogramming. The unsolved problems and further research direction in this new approach are also discussed in this review.
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