Home > Browse Issues > Vol.36 No.8
Research Advance of ADAMTS Proteinases
Wei Fanhua1, Zhang Yuying2*, Yu Xiuping3
1Agricultural College of Ningxia University, Yinchuan 750021, China; 2Jinan University School of Biological Science and Technology,Jinan 250022, China; 3Shandong University School of Medicine, Jinan 250012, China
Abstract: The ADAMTS proteinases are a group of multi-domain and secreted metalloproteinase containing the thrombospondin motifs. Mutations in the ADAMTS gene or overexpression of ADAMTS gene is associated with a variety of physiological and pathological processes. Overexpression of ADAMTS gene promotes the breakdown of extracellular matrix and accelerates the development of arthritis and atherosclerosis. Mutations in the ADAMTS gene are closely related to cancer cells growth and metastasis and human genetic disorders. This review based on our results and provided an overview of current knowledge of ADAMTS-7， including its structure， function，gene regulation and inflammatory disease involvement.
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