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Raf-1 Kinase and Tumor Therapy
Zhou Houqing, Liu Ying, Yang Yang, An Shu, Guo Xiaoxi, Xu Tianrui*
Cell Signaling Lab, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Abstract: Since Raf kinases were identified as products of retroviroal oncogenes， the Raf kineses have been intensively studied. Raf kinases are not only the bona fide effectors of the Ras， but also activators of the typical ERK signaling pathway， which provide an important link between Ras and ERK. Ras-Raf-MEK-ERK signaling pathway is involved in many biological process including cell proliferation， differentiation and apoptosis. As a node of the Ras-Raf-MEK-ERK signaling pathway， Raf kinases play a crucial role in tumorgensis. Raf-1， a key member of Raf family， regulates cell motility by controlling the activity of Rok-α， and apoptosis by suppressing the activity of the proapoptosis kinases， ASK1 and MST2. In this review， we described the regulation of Raf-1 kinase and its role in the tumorgensis. We also summarized the latest development in tumor therapy targeting Raf-1.
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