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Role of Filamin A in Cell Adhesion and Migraion
Zhu Dan, Xiang Shilong, Xue Zhimin, Wang Meihui, Zhou Binquan*, Fu Guosheng
Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China
Abstract: Cell migration is essential for development， tissue remodeling and wound healing， and is abnormal in many pathological states. Filamin A is an actin-binding protein and is widely expressed in various cell types. Mutations in filamin A gene are the cause of a wide range of genetic diseases， while abnormality in filamin A expression is resposible for cancer metastasis. Filamin A regulates cytoskeleton rearragement and palys a pivotal role in cell shape determination. Depletion of filamin A leads to obvious cell migration defects. In this review， we discuss the implication of filamin A in genetic diseases and cancer metastasis， emphasizing the impact of cell migration defects on these diseases. Further more， we discuss the role of filamin A on cell migration and its underlying mechanism.
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