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Review: Plant Polyphenols Modulate Lipid Metabolism by Regulating MicroRNA
Su Dongxiao1,2, Zhang Mingwei1, Zhang Ruifen1*
1Sericultural and Agri-food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China; 2Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Abstract: MicroRNA (miRNA) is small non-coding RNA molecule， about 21~25 nucleotides in length， which regulates gene expression at the post transcriptional level by decreasing the translation and/or stability of messenger RNA. Approximately 60% genes encoding proteins in human are modulated by miRNAs， including genes modulating lipids metabolism. Plant polyphenols can exert hypolipidemic activity by regulating the lipid metabolism related miRNAs， such as miR-122 and miR-33. This paper reviewed the advances in action mechanism by which miRNAs modulate lipids metabolism related mRNAs and the possible effect of plant polyphenols in such a bioprocess.
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