Home > Browse Issues > Vol.36 No.7
Progress on Post-translational Modification of Proteins
Ruan Banjun1, Dai Peng1, Wang Wei1, Sun Jianbin1, Zhang Wentao1, Yan Zhen1*, Yang Jinghua2*
1The State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, The Fourth Military Medical University, Xi’an 710032, China; 2Department of Surgery, VA Boston Healthcare System,Boston University School of Medicine, Boston MA02130, USA
Abstract: Although protein expression is regulated through genetics and epi-genetics， its function is determined by many factors， of which post-translational modification (PTM) is particularly important. Protein modifications are precisely regulated through a variety of modifiers and de-modifiers， most of which are yet to be defined. Most physiological or pathological processes are usually regulated through typical but complex and dynamic PTM patterns and networks. Reasonably， proteome of PTM is more precise to describe the physiological or pathological processes of cells at the molecular level to clarify protein functions and easy to find out biomarkers and molecule targets for disease diagnosis and drug development. Here we reviewed some common types of modifications of proteins and methods in PTM research.
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