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Advances in Familial Aggregation of Hepatocellular Carcinoma in Molecular Genetics
Zhang Cunzhen1,2, Cheng Yuqiang3, Guo Weixing2, Cheng Shuqun2*
1Graduate College, Soochow Uiversity, Suzhou 215006, China; 2Eastern Hepatobiliary Surgery Hospital,Second Military Medical University, Shanghai 200438, China; 3234th Hospital of PLA, Chaoyang 122000, China
Abstract: Many studies have shown that the incidence of cancer and heredity are closely related. For hepatocellular carcinoma (HCC)， the incidence of familial aggregation tendency is also obvious， and studies have shown that the people having a positive family history of HCC suffered from HCC far more than the chance of the negative ones， but the mechanism of HCC clusters of disease has not been fully explained. This paper reviewed the published papers about the familial aggregation of HCC to provide a theoretical basis for the research of the incidence of HCC.
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