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Expression of Galectin-7 and MMP-9 in Esophageal Squamous Cell Carcinoma and It’s Relationship with Early Postoperative Recurrence
He Congwen, Wang Bin*, Xiang Xiaoyong
Department of Caridiothoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Abstract: Examined the expressions of Galectin-7 and MMP-9 in esophageal squamous cell carcinoma (n=50) and noncencerous specimens (n=38) by immunohistochemistry to analyze the relationship between the expressions of Galectin-7， MMP-9 and the clinicopathological features. The expressions of Galectin-7 and MMP-9 were increased in esophageal squamous cell carcinoma (ESCC). The expressions of Galectin-7 and MMP-9 were correlated with TNM stages， invasive depths and lymph node metastasis. Positive correlation between Galectin-7 and MMP-9 were found in ESCC. For prognosis of early recurrence and metastasis， the specificity and sensitivity of combined detection of Galectin-7 and MMP-9 were both higher than detecting Galectin-7 or MMP-9 alone. Galectin-7 and MMP-9 might play an important role in the pathogenesis and progress of ESCC. Combined detection of Galectin-7 and MMP-9 could be helpful for prognosis of early recurrence and metastasis in ESCC.
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