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Application of Startle Response System in Study of Sensorimotor Gating of Mice
Wang Haoyue1, Huang Danyi1, Li Jun2, Wu wenting2, Ying Yue1, Wang Weigang2, Fei Jian1,2*
1School of Life Science and Technology, Tongji University, Shanghai 200092, China; 2Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: Dysfunction of sensorimotor gating is related to many kinds of psychiatric disorders. Prepulse inhibition， as a robust operational measure of sensorimotor gating， was tested in C57BL/6J mice using startle response system in this study. Furthermore， a mouse model of PPI disruption induced by MK-801， which is a noncompetitive antagonist of the N-methyl-D-aspartate receptor， was successfully established.
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