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Cell Cycle Determining the Accumulation of Human Ribosomal Protein S6 at the Nucleolus in Eukaryotes
Zhang Duo1,2, Lan Fenghua1, Gao Lihua2, Shao Yong2, Chen Huipeng2, Hu Xianwen2*
1Clinical Genetic Research Center, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025;2Beijing Institute of Biotechnology, Beijing 100071, China
Abstract: Ribosomal protein S6 (rpS6) is one of the 33 ribosomal proteins of the 40S small subunit. Previous studies have showed that rpS6 could enter nuclear and participate the ribosomal biogenesis at nucleolus. In this study， we found that the distribution of rpS6 at nucleolus correlated to the phasing of cell cycle. It started to concentrate in the nucleolus at later S phase and disconcentrated at M phase as the nucleolus disintegrates. We speculated that this distribution feature might correlate to the changes of ribosomal biogenesis during cell cycle progress.
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