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Progress in Structural and Functional Studies of Histone Methyltransferase MLL1
Li Yanjing, Chen Yong*
National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Histone H3K4 methyltransferase MLL1 has been intensively studied because of its involvement by chromosomal translocation in mixed lineage leukemia. MLL1 plays a pivotal role in gene regulation， development and differentiation. Chromosome translocations of MLL1 generate chimeric proteins containing MLL1 Nterminus fused in-frame with distinct partner proteins， which contribute to leukemogenesis. Recent progress has begun to reveal the structures and functions of MLL1 protein， which， in turn， have provided new opportunities for therapeutic development towards mixed lineage leukemia.
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