Home > Browse Issues > Vol.36 No.5
Autophagy and Virus Replication
Zhu Fei*, Wang Zhi
College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Lin’an 311300, China
Abstract: Autophagy is a highly conserved cellular degradation process in eukaryotes， playing an important role in the maintenance of cellular homeostasis. At the same time， autophagy contributes to the recognition of pathogenic microorganisms by innate immune system， and helps phagocytes to make an effective phagocytosis and clear extracellular or intracellular pathogens. However， the virus， especially the RNA virus， which has the capacity of rapid evolution to respond to the changes in the host cell， can make service for its replication through using or inhibiting autophagy. Therefore， drug screening and treatment strategies based on the autophagy pathway increasingly become a hot spot of antiviral research.
CN
EN