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Screening and Identification of Small Non-coding RNAs in Bacteria
Wang Liangyan1, Hong Qihua2, Hua Yuejin1*
1College of Agriculture & Biotechnology, Zhejiang University, Hangzhou 310029, China;2College of Animal Sciences, Zhejiang University, Hangzhou 310029, China
Abstract: Small non-coding RNAs (sRNAs) in bacteria are 50~500 nt small RNAs that do not encode proteins， but act as important regulators in response to stress， virulence and metabolism. Most small RNAs interact with target mRNAs through base-pairing to change their translation and stability so as to affect the activity of bacteria. Recently， hundreds of sRNAs have been explored in bacteria using bioinformatics combined with molecular biology techniques. This review focuses on the screening and identification of sRNAs in bacteria.
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