Home > Browse Issues > Vol.30 No.4
Regulation of Sertoli Cell on the Development of Spermatogonial Stem Cell
Lei Si, Xue-Ming Zhang*, Zhan-Peng Yue, Zi-Yi Li, De-Xue Li
Key Laboratory of Animal Embryo Engineering, Jilin Province; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China
Abstract: Spermatogonial stem cells (SSCs) are primordial spermatogonia resided on the base membrane of the seminiferous tubules in testes and being capable of self-renewal and differentiation. Due to their unique biological properties， investigations on SSCs are significantly important in stem cell biology， basic medicine， animal science and husbandry. However， the regulation mechanisms of SSCs self-renewal and differentiation is still unclear. The development of stem cell is controlled by the integration of intrinsic factors with its specific environment. Recently， the regulation of testicular Sertoli cells， the main structural component of this specialized environment on SSCs behavior， has raised extensive concern and progressed rapidly. Based on the related reports， this review focuses on current progress of the regulation of Sertoli cells in mammalian testis on SSCs self-renewal and differentiation in order to provide the clue for further studies in SSCs or other related stem cell researches.
CN
EN