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Rab Small GTPases and Motor Proteins in Vesicular Transport
Bei Tang*
Department of Biology, Chongqing Normal University, Chongqing 400047, China
Abstract: Rab are the largest subfamily of Ras superfamily of small GTP-binding protein， they function as regulators in different vesicular transport processes. When bound with GTP， the Rab can recruit specific sets of effector proteins onto membranes. Recently， a number of Rab were identified that regulate the transport of corresponding vesicle by recruiting microtubule- or actin-based motor proteins to their target membranes. The molecular switch property of Rabs may enable them to control vesicular transport in both spatial and timed manners.
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