Progress in Nuclear Translocation Pathway of Transmembrane Receptors

Abstract: Although transmembrane receptors from cell surface to nucleus can generally regulate the cellular life activities， their pathways of nuclear translocation still remain to be elucidated. Several modes have been suggested to explain the pathways of nuclear translocation of transmembrane receptors， which all emphasize that transmembrane receptors could translocate into nuclues following 'escape' from cell membrane or enodsomes into cytoplasm. Herein， a novel nuclear translocation pathway of transmembrane receptors is hypothesized as an endocytosis-sorting-concentration-fusion-translocation pathway model. It is helpful to understand the molecular mechanism of transmembrane receptors?nuclear translocation， and provide a promising research approach toward biomedicine and biotechnology， such as drugs target， gene therapy， gene engineering， and virus infection.

CSTR: 32200.14.cjcb.2008.04.0009