Characteristics of Cancer Cell Motility and the Quantitative Analysis of Cell Migration

Abstract: Characteristics and changes in cell motility are affected by the condition of cells as well as micro-environment， which influced cells?movement behavior to adjust to the different micro-environment. In the two-dimensional culture matrix， cell migration patterns can be divided as single migration or collective migration， and in three-dimensional cultivate their migration patterns cell undergo mesenchymal migration or amebic migration. Because of the abnormal conditions of structure and function， the cancer cell moving characteristics is in varying degrees of alienation contrast to normal cell. Quantify the abilities of cell migration contribute to the further understanding of nature. Based on the different cell culture environment， we introduced the two-dimensional and three-dimensional culture matrix cell migration patterns， stated the characteristics of tumor cell migration and movement， as well as the testing means and methods to measure cell migration in vitro， and we also analyze the pros and cons of the in vitro tests available to quantify quantitative of cell migration.
    

CSTR: 32200.14.cjcb.2008.04.0008