Aging-caused Fat Redistribution and Metabolic Dysfunction

Abstract: The total amount of fat mass and fat tissue distribution change dramatically throughout the life of a living being. In old age， fat mass is redistributed from subcutaneous site to abdominal viscera， bone-marrow， muscle， liver and other ectopic sites， which causes the dysfunction of adipose tissue and increases the risk of metabolic syndrome. With aging， declines in preadipocyte proliferation and differentiation contribute to increased systemic exposure to lipotoxic free fatty acids. Age-associated fat tissue inflammation is related to changes of preadipocyte and macrophage in a depot dependent manner. Fat tissue inflammation frequently leads to further decrease of lipogenesis， increase of lipotoxic and activation of cellular stress pathway， which aggravates the inflammation response of preadipocyte and immune cells， and leads to the systemic dysfunction finally. This review focused on the progress in the study of aging-caused fat redistribution and metabolic dysfunction.

CSTR: 32200.14.cjcb.2014.02.0020