Advances in the Genetic Study of X-linked Intellectual Disability

Lu ping¹, Zhu Xianmin¹, Xue Zhigang¹, Fan Guoping^2,3*

¹Stem Cell Research Center, Department of Regenerative Medicine, Tongji University School of Medicine, Tongji University,Shanghai 200092, China; ²School of Life Sciences and Technology and Advanced Institute of Translational Medicine

Abstract: X-linked intellectual disability (XLID) is a class of mental disorders caused by a variety of gene mutations on the X chromosome. XLID accounts for 15% of the cases of intellectual disability worldwide. Historically， XLID has been categorized into syndromic (S-XLID) and non-syndromic (NS-XLID) based on other physiological characteristics in addition to intellectual disability. S-XLID is characterized by intellectual and learning disability with other features such as body dysmorphic， metabolic and neuromuscular disorders. This mini-review summarizes recent advances in genetic studies of XLID.

CSTR: 32200.14.cjcb.2014.02.0019