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Effects of RhoA-regulated Cytoskeleton in the Tumorigenesis
Wang Xue1, Wang Weili1, Ren Yu2, Zhuang Haihui1, Wang Ping1*
1Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China; 2Department of Urologic Surgery, Ningbo Urology and Nephr
Abstract: RhoA is a small G-protein of Ras homolog gene family， which has the GTPase activity. Higher protein expression is tightly related with malignancy. Furthermore， RhoA activity controls the signal pathway and regulates cytoskeletal rearrangements. Recent reports showed that RhoA activity-induced cytoskeleton played a pivotal role in regulating cell behaviors. Accordance with our research， this review summarizes recent progress in studying the mechanisms of RhoA-mediated cytoskeleton in tumorigenesis.
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