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Expression of PRR11 in Gastric Cancer and Its Relationship with Prognosis
Ye Jianxin1, Zheng Wei1, Zhao Xintai2*
1Department of Gastroenterology, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005; 2Shanghai Shines Pharmaceuticals Company Limited; Research Base of Molecular Diagnosis Technology for Tumor Personalized Medici
Abstract: To detect PRR11 expression and determine its clinical significance in gastric cancer， tissue microarray blocks containing tumor specimens obtained from 167 patients with gastric cancer were constructed. Expression of PRR11 in human gastric cancer specimens was analyzed using immunohistochemistry (IHC) and Western blot. PRR11 was overexpressed in human gastric cancers compared with that in adjacent non-cancerous tissues by Western blot. IHC results showed that expression of PRR11 was observed in 85 cases (50.9%) of 167 primary gastric cancers. PRR11 expression was significantly associated with gastric wall invasion， lymph node metastasis， tumor progression and poor differentiation (P<0.05). PRR11 expression significantly correlated with poor outcome of patients with gastric cancer in univariate (45 months vs 81 months， P<0.001) and multivariate analyses (95% CI: 0.347~0.865， P=0.01). Our results showed that PRR11 expression significantly increased with the progression of human gastric cancer， suggesting the importance of PRR11 as a potential biomarker in cancer diagnosis and treatment.
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